The onset of action is about 1 to 2 minutes 80% response occurs within the first 3 minutes.The peak effect is 6 to 10 minutes after administration.The duration ranges from 19 minutes to 50 minutes, depending on the dose and benzodiazepine plasma concentrations. It can also reverse the binding of benzodiazepines to benzodiazepine receptors. It competitively inhibits the activity of benzodiazepine and non-benzodiazepine substances that interact with benzodiazepine receptors site on the GABA/benzodiazepine receptor complex. Mechanism of Actionįlumazenil is a benzodiazepine antagonist. Īs Flumazenil has not received approval from the FDA, the advantages and disadvantages of using this drug in non-FDA-approved conditions are based on the patient's condition and the physician's judgment. Flumazenil is more effective in reversing sedation or coma in benzodiazepine intoxication than patients with multiple drug overdoses.
It is useful in reversing coma due to benzodiazepine overdose.
Flumazenil is also indicated for the management and treatment of benzodiazepine overdose in adults.In addition, Flumazenil speeds the recovery from sedation following minor surgical procedures and shortened the post-operation monitoring period for minor surgery, resulting in earlier patient discharge. Flumazenil injection is indicated for a complete or partial reversal of the sedative effects of benzodiazepines in conscious sedation and general anesthesia in the adult and pediatric populations.Reversal of Postoperative Sedation from Benzodiazepine Anesthetics.Review interprofessional team strategies for improving care coordination and communication to advance flumazenil therapy and improve outcomes.įlumazenil is a benzodiazepine antagonist.Summarize the adverse events associated with flumazenil administration.Outline the indications for using flumazenil.Identify the mechanism of action of flumazenil.This activity outlines the indications, mechanism of action, dosing, significant adverse effects, contraindications, monitoring, and toxicity of flumazenil so that providers can direct patient therapy to optimal outcomes in benzodiazepine reversal.
Flumazenil injection is indicated for a complete or partial reversal of the sedative effects of benzodiazepines in conscious sedation and general anesthesia in adult and pediatric populations. The primary FDA-approved clinical uses for flumazenil include reversal agents for benzodiazepine overdose and postoperative sedation from benzodiazepine anesthetics. Flumazenil is a benzodiazepine antagonist.
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